Abstract
Selective left temporal infarction of rats was induced by cold light to investigate the role of temporal lobe in spatial cognition task. The reaction time and distance of the temporal infarcted rats in Morris water maze were all significantly longer than that of normal and sham operated rats. Compared with those of the controlled group, the change of behavioral strategies of the infarct group was slower than that of the normal and sham group. In conclusion, after the temporal infarction, the rats suffered spatial learning deficits. It will be helpful to establish the available cognitive deficits animal paradigm, and explore the effects of the drugs that can improve cognitive ability.
| Keywords: | temporal lobe; brain infarction; Morris water maze; spatial cognition |
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