Abstract
In this study the synaptic mechanism of scopolamine-induced memory dysfunction was investigated in the brain, the changes of the structure parameters of Gray I synaptic interface in the hippocampal CA3 area were quantitatively analyzed in mice model of scopolamine-induced memory dysfunction, and the effect of scopolamine on the incorporation of 3H-Leu into hippocampal symaptosomes was observed. The results showed that scopolamine could induce the thickness of post-synaptic density (PSD) thinned down significantly (P < 0.01), and reduced the incorporation of 3H-Leu into hippocampal symaptosomes apparently (P < 0.001). these results suggested that the scopolamine-included memory dysfunction may be based on the decrease of synaptosomal protein syntheses of cholinergic system, and the changes of the synaptic structural parameters in the brain.
| Keywords: | scopolamine, synaptic structural parameters; hippocampal CA3 area; memory dysfunction |
|---|
[Chinese Version | Index | Acta Psychologica Sinica | Other Journals | Subscription form | Enquiry ]
Mail any comments and suggestions to
hkier-journal@cuhk.edu.hk .