Abstract
Cyclophosphamide (CY), and immunosuppressive agent, was used as an unconditioned stimulus (UCS) in a conditioned taste aversion (CTA) paradigm with saccharin as the conditioning stimulus (CS) in a two-bottle preference drinking procedure. Conditioned behavioral and immunological responses were observed under both one trial of CS-UCS paring and two trials of CS-UCS paring. Data showed that CTA occurred under both one trial and two trials of CS-UCS paring, but conditioned immunosuppression, as assessed by spleen cell proliferation to mitogen and the number of peripheral leukocyte and lymphocyte, required 2 parings. These results suggest that conditioned behavioral and immunological changes might occur independently.
| Keywords: | cyclophosphamide; conditioned immunosuppression; conditioned taste aversion |
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