Abstract
Central interleukin-1 (IL-1) plays very important roles in mediating the neural, endocrine, and behavioral responses to stressors. Furthermore, cardiovascular and endocrine responses to interleukin-1β are similar to stress. To test the roles of central IL-1 in hypertension induced by stress (footshock or conditional fear emotional stress), intracerebral ventricular (ICV) injection of IL-1β or IL-1ra was performed on male Sprague-Dawley rats. We observed that: (1) ICV injection of interleukin-1β induced pressor responses. (2) Hypertension induced by interleukin-1β was blocked by ICV injection of an IL-1 antagonist, IL-1ra. (3) ICV injection of IL-1ra attenuate the pressor response induced by footshock but intravenous injection of IL-1ra did not significantly reduce this response. (4) The hypertensive response to conditioned fear stimuli was reversed by ICV injection of IL-1ra. These results suggested that the pressor response induced by footshock or conditioned fear emotional stimuli is mediated by central interleukin-1.
| Keywords: | hypertension; interleukin-1; interleukin-1 receptor antagonist; footshock; conditioned fear emotional stimuli |
|---|
[Chinese Version | Index | Acta Psychologica Sinica | Other Journals | Subscription form | Enquiry ]
Mail any comments and suggestions to
hkier-journal@cuhk.edu.hk .