Abstract
Central interleukin-1 plays important roles in mediating the neural, endocrine and behavioral responses to various stressors. The aim of this study is to investigate the effect of adenosine in interleukin-1β-induced behavioral depression in rats. Methods: Porsolt swim test was used for the measurement of behavioral depression after injection of interleukin-1β (8–32ng/kg, icv) and nonspecific adenosine receptor antagonist-caffeine and specific adenosine receptor antagonist (A1 and A2) was used to determine the effect of adenosine in interleukin-1β-induced behavioral depression. Results: Injection of interleukin-1β (8–32ng/kg, icv) induced increases of floating time in Porsolt swim test. Pretreatment with caffeine and A2a adenosine receptor antagonist blocked interleukin-1β-induced increase of floating time. Conclusion: Intracerebroventricular injection of interleukin-1β-induced behavioral depression in rats, which could be blocked by A2a adenosine receptor antagonist.
| Keywords: | interleukin-1; behavioral depression; adenosine |
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