Abstract
The influence of nimodipine (ip) on chemical learning and memory dysfunction from intrahippocampal injection of CaCI2 and scopolamine were investigated, and the effects of three agents (CaCI2, scopolamine and nimodipine) on the incorporation of 3H-Leu into hippocampal symaptosomes were observed. The results showed that intrahippocampal injection of CaCI2 and scopolamine could cause chemical learning and memory dysfunction significantly (p < 0.01 and p < 0.05), nimodipine could ameliorate chemical learning and memory dysfunction obviously (p < 0.05 and p <0.01), CaCI2 and scopolamine could reduce incorporation of 3H-Leu into hippocampal symaptosomes apparently (p < 0.01 and p < 0.001), but, in vitro, it couldn’t antagonize the reduction of incorporation of 3H-Leu into hippocampal symaptosomes resulted from these two agents. These results suggested that there might exist other mechanism of Ca2+ channel antagonist nimodipine on ameliorating memory impairment instead of improving synaptosomal protein syntheses.
| Keywords: | nimodipine; CaCI2; scopolamine; memory dysfunction; amelioration |
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